The boundary conditions and assumptions for safety assessments and calculations of residual error rates are listed here.

Generally:

Even for safety functions that do not require manual operator acknowledgment for restart, manual operator acknowledgment is mandatory whenever the SafetyConsumer has detected certain types of errors and indicates this using OperatorAckRequested. Hence, operator acknowledgment is expected to be implemented by the safety application whenever OPC UA Safety is used. For details, see 6.3.4.3 and Clause B.2.