EPCIS documents shall conform with GS1's EPCIS and Core Business Vocabulary (CBV) standards (i.e., ISO/IEC 19987 and 19988, respectively).

Additional guidance is provided by GS1's global, cross-sector EPCIS and CBV Implementation Guideline, as well as by the pharmaceutical supply chain-specific, GS1 US implementation guideline, “Applying GS1 Standards for DSCSA and Traceability”.