OPC UA uses Symmetric and Asymmetric Encryption to protect Confidentiality as a security objective. Thereby Asymmetric Encryption is used for key agreement and Symmetric Encryption for securing all other Messages sent between OPC UA Applications. Encryption mechanisms are specified in OPC 10000-6 and OPC 10000-14.

OPC UA relies upon the site CSMS to protect Confidentiality on the network and system infrastructure. OPC UA relies upon the PKI to manage keys used for Asymmetric Encryption which is then used to establish symmetric session keys.